MersV1, Main, Exploration, bibRecord, 003F15

Transfer of exogenous glycosylphos-phatidylinositol (GPI)-linked molecules to plasma membranes

Identifieur interne : 003F15 ( Main/Exploration ); précédent : 003F14; suivant : 003F16

Transfer of exogenous glycosylphos-phatidylinositol (GPI)-linked molecules to plasma membranes

Auteurs : Subburaj Ilangumaran [Suisse] ; Peter J. Robinson ; Daniel C. Hoessli [Suisse]

Source :

Trends in Cell Biology [ 0962-8924 ] ; 1996.

RBID : ISTEX:C7020284F13AFAA17F0C84ED20CA19FE5F1AC387

English descriptors

Teeft :
- Acceptor, Acceptor cell membranes, Acyl, Acyl chains, Antigenic peptide, Cell biology, Cell surface, Complement activation, Detergent molecules, Erythrocyte, Exogenous, Exogenous molecules, Host bloodstream, Host cells, Immunol, Ligand binding, Membrane, Membrane vesicles, Molecule, Parasite, Plasma membrane, Plasma membranes, Sheep erythrocytes, Specific receptors, Target cell membrane, Target cells, Transgenic hearts, Transmembrane proteins, Trypanosoma brucei, Tumour cells, Virulence factors, Vivo.

Abstract

Abstract: Purified GPI-linked molecules incorporate spontaneously in vitro into mammalian cell plasma membranes. Recent evidence suggests that the transferred molecules insert stably into the external leaflet of the acceptor cell plasma membrane through their acyl chains and behave subsequently in a way similar to endogenous GPI-linked molecules. Transfer of GPI-linked proteins between cells has also been documented in vivo and may explain the uptake by host cells o f pathogen-derived virulence factors carrying a GPI anchor. In this comment article, Subburaj Ilangumaran, Peter Robinson and Daniel Hoessli review what is known about GPI transfer and discuss the use of GPI transfer for transient cell-surface expression of foreign proteins.

Url:

https://api.istex.fr/ark:/67375/6H6-0KL8PFZS-Z/fulltext.pdf

DOI: 10.1016/0962-8924(96)20012-1

Affiliations:

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Le document en format XML

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<term>Cell biology</term>
<term>Cell surface</term>
<term>Complement activation</term>
<term>Detergent molecules</term>
<term>Erythrocyte</term>
<term>Exogenous</term>
<term>Exogenous molecules</term>
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<front><div type="abstract" xml:lang="en">Abstract: Purified GPI-linked molecules incorporate spontaneously in vitro into mammalian cell plasma membranes. Recent evidence suggests that the transferred molecules insert stably into the external leaflet of the acceptor cell plasma membrane through their acyl chains and behave subsequently in a way similar to endogenous GPI-linked molecules. Transfer of GPI-linked proteins between cells has also been documented in vivo and may explain the uptake by host cells o f pathogen-derived virulence factors carrying a GPI anchor. In this comment article, Subburaj Ilangumaran, Peter Robinson and Daniel Hoessli review what is known about GPI transfer and discuss the use of GPI transfer for transient cell-surface expression of foreign proteins.</div>
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Transfer of exogenous glycosylphos-phatidylinositol (GPI)-linked molecules to plasma membranes

Transfer of exogenous glycosylphos-phatidylinositol (GPI)-linked molecules to plasma membranes

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri